Daisy Hu
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Genomics and Bioinfo
Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization
Abstract: Mutations in fused in sarcoma (FUS) lead to amyotrophic lateral sclerosis (ALS) with varying ages of onset, progression and…
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In vivo engineered extracellular matrix scaffolds with instructive niches for oriented tissue regeneration
Abstract: Implanted scaffolds with inductive niches can facilitate the recruitment and differentiation of host cells, thereby enhancing endogenous tissue regeneration.…
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Agricultural and Food
Genome-wide associated study identifies NAC42-activated nitrate transporter conferring high nitrogen use efficiency in rice
Abstract: Over-application of nitrogen fertilizer in fields has had a negative impact on both environment and human health. Domesticated rice varieties…
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Environmental Biotech
Designing yeast as plant-like hyperaccumulators for heavy metals
Abstract: Hyperaccumulators typically refer to plants that absorb and tolerate elevated amounts of heavy metals. Due to their unique metal…
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Genomics and Bioinfo
Two-tiered enforcement of high-fidelity DNA ligation
Abstract: DNA ligases catalyze the joining of DNA strands to complete DNA replication, recombination and repair transactions. To protect the…
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Genomics and Bioinfo
A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells
Abstract: Elevated glucose consumption is fundamental to cancer, but selectively targeting this pathway is challenging. We develop a high-throughput assay…
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Genomics and Bioinfo
RNA dynamics live
A series of bright fluorescent RNAs enable imaging of RNA in live cells. This original image shows heterogeneity of protein…
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Animal biotechnology
Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors
Abstract: The fusion of genome engineering and adoptive cellular therapy holds immense promise for the treatment of genetic disease and…
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Genomics and Bioinfo
Pathways to cellular supremacy in biocomputing
Abstract: Synthetic biology uses living cells as the substrate for performing human-defined computations. Many current implementations of cellular computing are…
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Environmental Biotech
Microbial reduction of metal-organic frameworks enables synergistic chromium removal
Abstract: Redox interactions between electroactive bacteria and inorganic materials underpin many emerging technologies, but commonly used materials (e.g., metal oxides)…
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