Publications

    Recent advances in microfluidic platforms for single-cell analysis in cancer biology, diagnosis and therapy

    Recent advances in microfluidic platforms for single-cell analysis in cancer biology, diagnosis and therapy

    Understanding molecular, cellular, genetic and functional heterogeneity of tumors at the single-cell level has become a major challenge for cancer…
    Robust, reproducible and quantitative analysis of thousands of proteomes by micro-flow LC–MS/MS

    Robust, reproducible and quantitative analysis of thousands of proteomes by micro-flow LC–MS/MS

    Abstract: Nano-flow liquid chromatography tandem mass spectrometry (nano-flow LC–MS/MS) is the mainstay in proteome research because of its excellent sensitivity…
    Forces during cellular uptake of viruses and nanoparticles at the ventral side

    Forces during cellular uptake of viruses and nanoparticles at the ventral side

    Abstract: Many intracellular pathogens, such as mammalian reovirus, mimic extracellular matrix motifs to specifically interact with the host membrane. Whether…
    Long-read sequencing reveals genomic structural variations that underlie creation of quality protein maize

    Long-read sequencing reveals genomic structural variations that underlie creation of quality protein maize

    Abstract: Mutation of o2 doubles maize endosperm lysine content, but it causes an inferior kernel phenotype. Developing quality protein maize…
    Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells

    Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells

    Abstract: Single-strand breaks (SSBs) represent the major form of DNA damage, yet techniques to map these lesions genome-wide with nucleotide-level…
    Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease

    Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease

    Abstract: Autosomal dominant polycystic kidney disease (ADPKD) caused by PKD1 mutations is one of the most common hereditary disorders. However,…
    Gene therapy for progressive familial intrahepatic cholestasis type 3 in a clinically relevant mouse model

    Gene therapy for progressive familial intrahepatic cholestasis type 3 in a clinically relevant mouse model

    Abstract: Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare monogenic disease caused by mutations in the ABCB4 gene,…
    Giant single molecule chemistry events observed from a tetrachloroaurate(III) embedded Mycobacterium smegmatis porin A nanopore

    Giant single molecule chemistry events observed from a tetrachloroaurate(III) embedded Mycobacterium smegmatis porin A nanopore

    Abstract: Biological nanopores are capable of resolving small analytes down to a monoatomic ion. In this research, tetrachloroaurate(III), a polyatomic…
    Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization

    Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization

    Abstract: Mutations in fused in sarcoma (FUS) lead to amyotrophic lateral sclerosis (ALS) with varying ages of onset, progression and…
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