Nature Collection

Nature journals

Robust, reproducible and quantitative analysis of thousands of proteomes by micro-flow LC–MS/MS

Robust, reproducible and quantitative analysis of thousands of proteomes by micro-flow LC–MS/MS

Abstract: Nano-flow liquid chromatography tandem mass spectrometry (nano-flow LC–MS/MS) is the mainstay in proteome research because of its excellent sensitivity…
Forces during cellular uptake of viruses and nanoparticles at the ventral side

Forces during cellular uptake of viruses and nanoparticles at the ventral side

Abstract: Many intracellular pathogens, such as mammalian reovirus, mimic extracellular matrix motifs to specifically interact with the host membrane. Whether…
Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells

Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells

Abstract: Single-strand breaks (SSBs) represent the major form of DNA damage, yet techniques to map these lesions genome-wide with nucleotide-level…
Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease

Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease

Abstract: Autosomal dominant polycystic kidney disease (ADPKD) caused by PKD1 mutations is one of the most common hereditary disorders. However,…
Gene therapy for progressive familial intrahepatic cholestasis type 3 in a clinically relevant mouse model

Gene therapy for progressive familial intrahepatic cholestasis type 3 in a clinically relevant mouse model

Abstract: Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare monogenic disease caused by mutations in the ABCB4 gene,…
Giant single molecule chemistry events observed from a tetrachloroaurate(III) embedded Mycobacterium smegmatis porin A nanopore

Giant single molecule chemistry events observed from a tetrachloroaurate(III) embedded Mycobacterium smegmatis porin A nanopore

Abstract: Biological nanopores are capable of resolving small analytes down to a monoatomic ion. In this research, tetrachloroaurate(III), a polyatomic…
Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization

Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization

Abstract: Mutations in fused in sarcoma (FUS) lead to amyotrophic lateral sclerosis (ALS) with varying ages of onset, progression and…
In vivo engineered extracellular matrix scaffolds with instructive niches for oriented tissue regeneration

In vivo engineered extracellular matrix scaffolds with instructive niches for oriented tissue regeneration

Abstract: Implanted scaffolds with inductive niches can facilitate the recruitment and differentiation of host cells, thereby enhancing endogenous tissue regeneration.…
Genome-wide associated study identifies NAC42-activated nitrate transporter conferring high nitrogen use efficiency in rice

Genome-wide associated study identifies NAC42-activated nitrate transporter conferring high nitrogen use efficiency in rice

Abstract: Over-application of nitrogen fertilizer in fields has had a negative impact on both environment and human health. Domesticated rice varieties…
Designing yeast as plant-like hyperaccumulators for heavy metals

Designing yeast as plant-like hyperaccumulators for heavy metals

Abstract: Hyperaccumulators typically refer to plants that absorb and tolerate elevated amounts of heavy metals. Due to their unique metal…
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